Pharmaceutical Chemistry

Objectives

Information available soon.

Program

THEORETICAL:
Introduction to Pharmaceutical Chemistry: generalities
Molecular recognition
Properties affecting drug activity
Metabolism as an interdisciplinary area
Discovery and development of new drugs
Hit-to-lead chemistry
Chemical structures, methods of obtaining, mechanisms of action, structure-activity relationship, metabolism and applications of the following groups of drugs:
General anesthetics
Local anesthetics
Hypnotics, sedatives, and anxiolytics
Antipsychotics
Antidepressants
Parkinson and Alzheimer
Centrally acting analgesics
Analgesics, anti-inflammatory and antipyretics
Steroids and related therapeutic compounds
Antihistamines
LABORATORIAL:
Pharmacopeial analysis: Quality control in specialty pharmaceuticals / raw materials.
Use of online tools: The Merck Index; The protein Data Bank; Click2Drug; Drugbank; PubChem; Infomed; Online Therapeutic Record; European Medicines Agency (EMA).
Preparation and oral presentation about an active substance.
Execution, analysis and interpretation of the fundamentals of laboratory work, namely:
Preparation of solid mixtures by crystallization.
Crystallization of benzoic acid.
Aspirin synthesis.
Tests for purity of alcohol.
Extraction of propranolol from tablets.

Teaching Methodologies

THEORETICAL TEACHING: 3 h / week:
Magistral component with expository lectures, using presentations, films, case studies of chemical/therapeutic classes and scientific research work. Classes of clarification of doubts and application of concepts with the realization of exercises formulated by the teacher.
The documents to support the classes are available on Moodle platform.
LABORATORY TEACHING: 3 h / week:
Execution of experimental work in the laboratory. Oral presentation of a work on an active substance, in the context of inverted classes, where group work, autonomy, critical thinking and the integration of digital skills in education are privileged.
The documents to support the classes are available on Moodle platform.

Bibliography

British Pharmacopeia, British Pharmacopeia Commision, The Stationary Office, London, 2001;

M.M. Pinto, H.M. Cidade; Obtenção de complexos de inclusão; Inclusion complex of Diazepam with Cyclodextrins in Solid Phase, Pratical Studies for Medicinal Chemistry, Exercise 1.8, Ed., CYTED, 2006;

C.M. Corrêa; Latenciação do Sulfatiazol" Práticas de química farmaceutica y medicinal, M.A.F. Prado e E.J. Barreiro, Ed., CYTED, 92-94, 2002;

E.J. Barreiro; Química medicinal: as bases moleculares da ação dos fármacos. ISBN: 85-7307-782-4;

United States Pharmacopeial Convention, Inc.; The United States pharmacopeia. ISBN: 1-889788-10-4;

C. Avendano; Introduccion a la quimica farmacêutica, McGaw Hill-Interamerica de Espana, 2001;

Martindale The Complete Drug Reference, 33Th Ed., Pharmaceutical Press, London, 2002;

R.B. Silverman.; The organic chemistry of drug design and drug action. ISBN: 0-12-643732-7;

R.J.S. Hickman, J. Neill; Influence of pH on drug absorption from the gastrointestinal tract, J. Chem. Ed.,74 (7), 855-856, 1997;

M.A.F. Prado; Determinação de constantes hidrofóbicas de substituintes de sulfonamidas por meio de cromatografia em camada delgada em fase reversa”, Prácticas de química farmacêutica y Medicinal do Sulfatiazol, Ed,. CYTED, 8-11, 2002;

N. Thomas; Medicinal chemistry: a biochemical approach. ISBN: 0-19-505369-9;

Comissão da Farmacopeia Portuguesa; Farmacopeia Portuguesa VIII. ISBN: 972-8425-67-8;

G.L. Patrick; An introduction to medicinal chemistry. ISBN: 0 19 850533 7;

M.M. Pinto; Manual de trabalhos laboratoriais de química orgânica e farmacêutica. ISBN: 978-972-757-750-7.