Molecular genetics

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Objectives

Study of the basic mechanisms that allow the transmission of information contained in DNA, taking into account the replication processes, transcription, processing and translation. Analysis of occurring DNA changes as a consequence of recombination mechanisms, mutation, transposition, and viral transduction. Study the mechanisms by which DNA repair. The study of the regulation of gene expression in prokaryotes and eukaryotes, as well as the molecular mechanisms associated with cancer induction, considering the existence of anti-oncogenes and oncogenes and their relationship to cell cycle regulation, in order to understood and analyzes the resulting consequences of changes in the expression of genes and their proteins. The use of recombinant DNA techniques and their applications: in gene cloning and identification, assessment of gene expression, diagnosis of diseases, in the production of drugs and vaccines and gene therapy. 

Program

Composition and structure of DNA, genes and chromosomes Mechanisms involving the transfer of genetic information taking into account DNA replication, transcription processes, RNA processing, and translation, in both eukaryotic and prokaryotic Modifications to the DNA molecule due to genetic recombination processes, the presence of mutations and viral agents. Mapping. DNA repair mechanisms in eukaryotes and prokaryotes. Regulation of gene expression in prokaryotes and eukaryotes. Molecular mechanisms of cancer induction. Oncogenes and anti-oncogenes. Relationship with cell cycle regulation. Use of recombinant DNA techniques and
its applications.

Teaching Methodologies

On the first day of classes are provided to the students all theoretical and practical background of the topics of UC. Lectures are supported with slideshows. The theoretical exam will cover all the subjects taught in the theoretical component (16 points in a 0-20 scale) or, alternatively, may be held by two frequencies, one in the week of midterm and one at the end of the semester (the date of the final exam) .Students to have approval at this UC must get a rating equal to or greater than 9.5 on a scale of 20 points, at the final exam or in both frequencies A minimum grade of 9.5 (a scale of 0-20) in laboratory examination (to be held in the last week of classes or resource time) is required for the student to access the 2nd frequency or the final theoretical exam. The laboratory exam will focus on the theoretical-practical and laboratory component. There is no one oral exams.

Bibliography

Information available soon.

Code

01101200

ECTS Credits

6

Classes

  • Práticas e Laboratórios - 26 hours
  • Teóricas - 39 hours