Definition of immune system. Identification of their cellular and humoral components. Study its interactions with molecular, cellular and biochemical mechanisms, that are important to organism protection; the consequences of a disorder of this regulatory system. To develop competencies and understand the means and basic laboratory techniques in the immunology diagnosis.
The immune s ystem (IS). Cells, tissues and organs of the IS. Lymphoid system. Complement and kinins. Adaptive immunity. Antigens and immunogens. Antibodies (immunoglobulins): structure and classes of immunoglobulins. Antigen antibody interaction. Major histocompatibility comp lex. Antigen processing and presentation. Differentiation and maturation of T cell activation Generation, activation a nd differentiation of B cells. Cytokines and receptors. Cell interaction in antibody response. Cell-mediated cytotoxicity. Immune disorders and hypersensitivity . Regulation of IS: tolerance and reje ction. Evolution of IS. Immune response to microbial and parasitic infections. Immune response to tumors. Immunity of the fetus and newborn. Immunoprophylaxis and immunotherapy. Fundamental rules of animal handling and biological materials. Agglutination and precipitation reactions: reactions of agglutination and blood groups. Production of monoclonal and polyclonal antibodies. ELISA.
Thematic theoretical presentation in a expository for m and interaction with students encouraging the discussion and connection of different knowledge.
In practical classes, students realy p erform the protocols of basic techniques in immunology, but with innocuous material that mimic the results of a real situation.
Students can be evaluated in:
1- Continuous assessment
Presence in 70% of the clas ses and active participation and interest in pratical classes, having critical thinking. Completion and presentation of a working group with the application of techniques learned in practice and related to the vererinary reality.
Writing test involving theory and practice knowledge (Minimum of 9 values) ;for continuous assessment. On examination, minimum of 9.5
Final score= positive test (70% ) + group work (30%) (50% written work, presentation and discussion 50%).
2- Additional assessment
3-Final Exam.
de Fernando A. Arosa, Francisco C. Pacheco, Elsa M. Cardoso. Fundamentos de Imunologia
Pires, Maria dos Anjos, Coelho, Ana Claúdia, Palmeira, Carlos, Cardoso, Maria das Neves Pai va, Seixas, Fernanda, &
Rodrigues, Jorge. Protocolos de Imunologia
Pires, Maria dos Anjos & Payan-Carreira, Rita . Sistema Fagocítico Mononuclear
Tizard, Ian R. Veterinary Immunology
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