Knowledge of the metabolic routes of vegetal biosynthesis and secondary metabolites. Use of plants in therapeutics: as source of bioactive molecules directly used by pharmaceutical industry (especially alkaloids and cardiotonics) and of molecules to be used as basis in semi-synthesis of other compounds for therapeutic application, or as leading structures for the study of new molecules with therapeutic interest (mainly steroids and alkaloids).
Knowledge of secondary metabolites from natural sources more often used as the active principles in current therapeutic.
1. Mevalonate and 1-Deoxy-D-xylulose/ 2-C-methylerythritol 4-phosphate pathways
2. Essential oils
3. Iridoids and secoiridoids
4. Resinous drugs
5. Saponosides
6. Cardiotonics
7. Incorporation of nitrogen in the biosynthetic pathways of plants
8. Glucosinolates
9. Cyanogenic compounds
10. Alkaloids
10.1. Generalities
10.2. Ornithine derivatives
10.3. Lysine derivatives
10.4. Nicotinic acid derivatives
10.5. Phenylalanine and tyrosine derivatives
10.6. Tryptophane derivatives
10.7. Histidine derivatives
10.8. Terpenic alkaloids
11. Xanthines
12. Bioactive compounds from marine animals: saponosides (triterpenic and steroid) and alkaloids
13. Bioactive compounds from frogs
Blended-learning: supporting material will be available in the e-learning plataform of U.Porto.
Theoretical education: 2h/week.
Laboratorial education: 2h/week.
Bruneton, J. Pharmacognosie, Phytochimie, Plantes Médicinales. Ed. TEC & DOC, Paris, 4ª ed., 2009.
Costa, A.F. Farmacognosia, volume III. Fundação Calouste Gulbenkian, Lisboa, 3ª ed., 2001.
Proença da Cunha, A. Farmacognosia e Fitoquímica. Fundação Calouste Gulbenkian, Lisboa, 4ª ed, 2014.
Farmacopeia Portuguesa IX.
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