Applied Mollecular Biology

Objectives

Information available soon.

Program

1. The aim of Molecular Biology in Medicine
2. Major techniques in Molecular Biology: Principles, fundamentals and applications to the study of the mechanisms of disease and
drug resistance
3. Cell signaling and Practical applications of the growth factors in hematology: hematopoietic stem cell transplantation
4. The Ribossomopathies and diseases of spliceosome: molecular characteristics, clinical and therapeutic implications
5. Introduction to Molecular Biology of Cancer
5.1 Cellular and molecular mechanisms involved in the development/progression of cancer and metastasis
5.2 Molecular mechanisms of sensitivity and resistance to chemotherapy
6. Molecular Biology of transfusional medicine
7. Molecular biology of pain, muscular dystrophies, asthma and pulmonar emphysema
8. Molecular Biology of Aging and Neurological diseases. New targeted therapeutic approaches. Recombinant proteins and gene
therapy. Understanding Pharmacogenetics and Pharmacoepigenomis

Teaching Methodologies

Learning molecular biology, as in other curricular units, is a multistep process, from acquisition, retention and retrieval of information to the ability to apply that information to new situations. Thus, in this curricular unit these cognitive principles will be applied, using for that purpose an integrated education based on theoretical, theoretical-practical and practical classes and seminars.

Bibliography

Weaver, Robert F. (2008). Molecular Biology, 4ª ed. McGraw-Hill.
Epstein, Richard J. (2003). Human Molecular Biology :An Introduction to the Molecular Basis of Health and Disease. 1ª ed.
Cambridge.
Regateiro, Fernando J. (2003). Manual de Genética Médicaâ€. 1.ª ed. Imprensa da Universidade de Coimbra.
Ameziane, Nedjima, Bogard, Marc, Lamoril, Jérôme (2006). Principes de Biologie Moleculaire en Biologie Clinique.Elsevier.
Lodish, Harvey; Berk, Arnold; Kaiser, Chris A. [et.al.] (2008). Molecular Cell Biology. 6ª ed. W. H. Freeman and Company.
Coleman, William B.; Tsongali, Gregory J. (2009). Molecular pathology: the molecular basis of human disease. Academic Press.
Runge, MarschallS.; Patterson, Cam (2006). Principles of Molecular Medicine. Second edition. Totowa, NJ, Humana Press
Cooper , Geoffrey M. (2004). The Cell: A Molecular Approach.
Artigos científicos e slides das aulas.