This teaching module provides a first of integrates quantitative methods in evidence based medicine, with an emphasis on the relevance of association and causality in Medicine. It precedes ensuing optional or obligatory semesters on quantitative Methods on Fundamental, Pre-clinical and Translational Research. In this first block, the student learns to understand how biostatistical methods can be used to infer population characteristics based on appropriate samples.
Statistical inference, in particular hypothesis testing, will be emphasized. Definition of critical p values in
relation to the compromise between different types of errors. and extension to analysis of variance and
regression methods.
Descriptive Statistics
Sampling approaches.
Statistical Inference
Probability, risk and odds
Estimation of Confidence Intervals
Sample based estimation of the difference of parameter values across distinct populations.
Hypothesis testing for differences across two groups
Hypothesis testing for the ratio across two groups
Hypothesis testing for the equality of proportions across two groups: chi-square tests
Measuring association between two variables
Measuring concordance
Linear regression
Analysis of variance
A theoretical class will include (1): a concise review of the material to be covered and its links to previous classes. A theoretical and conceptual analysis is then provided. The next phase (2) is oriented towards problem based learning using practical examples. Given that in the theoretical classes we discuss problem solving techniques this provides a direct link to the independent material shown in the practical classes.
Assessment:
Exam:50%
Midterm exam:
Test:25%
Project:
Seminar or study visit report:
Problem solving report:25%
Research work:
Synthesis work:
Fieldwork or laboratory work:
Other:
• Bernard Rosner Fundamentals of Biostatistics 2006 Thomson Brooks/Cole 868 p ISBN:0534418201
• Daly & Bourke Interpretação e aplicações da estatística em Medicina Ed. Instituto Piaget, 2000
• Massad, Menezes, Silveira & Ortega Métodos Quantitativos em Medicina ed. Manole, 2004.
• Betty Kirkwood and Jonathan Sterne Essential Medical Statistics Publisher: Wiley-Blackwell; 2nd Edition edition (8 May 2003)
• David Machin, Michael J. Campbell The Design of Studies for Medical Research ISBN: 978-0-470-84495-3, 286
pages February 2005, ©2005
• Artigos de biomedicina - Versões pdf disponibilizadas pelo corpo docente
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