Functional Biology

Objectives

This course is part of a set that is intended to be a deepening of key concepts in biology, in this case of Functional Biology. As standardizing concept of teaching content / learning was chosen "molecular mechanisms" and as specifier concept the study of mechanisms associated with responses of the body to disease or changes in mechanisms leading to disease were chosen. At the end of this unit is intended that students should identify and analyze human relate mechanisms involved in the physiological processes that relate to fight pathological processes and pathologic processes in order to focus on the specialty of the Master - Biomedicine.

Program

1. Immunity mechanisms

1.1. Elements and function of the immune system. Hematopoiesis;

1.2. Mechanisms of phagocytosis; toxicity of dendritic cells; and activation of complement action; activation of B lymphocytes, synthesis and action of antibodies; activation and action of T lymphocytes.

1.3. Action of immune system components in infectious and inflammatory processes

2) Coagulation and fibrinolysis mechanisms

2.1. Molecular mechanisms of the formation of a platelet trombolo; clot formation; fibrinolysis.

3. Functions of ion channels in homeostasis. Canelopatias.

3.1. Functional hierarchy of metazoan organisms.

3.2. Material exchange in the body. Concept of homeostasis.

3.3. The importance of ion distribution inside and outside the cell. Pumps, channels and transporters.

3.4. Anomalies in the channels and pathological consequences (canelopatias).

4. Practical component: Demonstration of phagocytosis processes and coagulation-forming fibers.

Teaching Methodologies

Teaching methods and learning activities:

In this unit we intend to develop a teaching / learning active student-centered. So the teacher after presenting the different themes propose learning tasks in groups. The theoretical group work will be conducted using the internet.

Bibliography

Arthur C. Guyton and John E. Hall. Textbook of Medical Physiology. 10th edition. W.B. Saunders Company, Philadelphia, Pennsylvania (2005).

William Ganon. Review of Medical Physiology. 22nd edition. W.B. Mac Graw Hill Companies (2005).

Bibliografia específica de “Mecanismos imunitários”

Tamàs et al. 2003. Arthritis Res Ther, 5:290-302

Louise et al. 2004. Brain, Behavior, and Immunity 18: 114–119.

Selena et al. 2010. PNAS 107 (17):| 7625–7626

Bibliografia específica de “coagulação e fibrinolise”

Butenas and Mann. 2002. Biochemistry (Moscow), Vol. 67, No. 1, pp. 3-12.

Dobrovolsky and Titaeva. 2002. Biochemistry (Moscow), Vol. 67, No. 1. pp. 99-108.

Feng et al. 2009. J Neurosci. 29(17): 5666–5670.

Bibliografia específica de “Funções dos canais iónicos na Homeostasia. Canelopatias”

Michael et al. 2006. Nephrol Dial Transplant: 21: 2708–2717.

Jurkat-Rott and Lehmann-Horn. 2007. Neurotherapeutics:4: 216–224.

Noone and Knowles. 2001Respir Res, 2:328-332