Quality and Safety Laboratory

Objectives

General learning outcome:

To recognize the need to implement "Good Laboratory Practices (GLP)" for the chemical and microbiological laboratories.

Specific learning outcomes:

1. To recognize the properties and associated risks with hazardous chemical products and biological agents and to be trained in their handling.

2. To recognize signs of exposure and to provide the first aid if necessary.

3. To use appropriate personal and collective protective equipment.

4. To recognize the basic rules for preventing accidents in the laboratory and to implement appropriate procedures in the case of emergencies.

5. To be able to adapt the workplace and procedures to avoid/minimize the risk of exposure.

6. To recognize the new European legislation on hazardous chemical substances (REACH-CLP/GHS) and the NP EN ISO 17025:2005 as support for quality laboratory certification.

Program

1. Chemical and biological risks.

1.1. General concepts: hazardous chemical products and biological agents (HCPBA); basic concepts of Toxicology.

1.2. Common accidents with HCPBA.

1.3. Effects caused by the exposure to HCPBA.

2. Identification, classification, associated hazards and properties of HCPBA. Labels. MSDS sheets. Signaling.

3. Personal and collective protection equipment.

3.1. Characteristics and protection afforded.

3.2. Selection criteria.

4. Handling, storage, transport and waste treatment of HCPBA: principles, risks and safety procedures.

5. General rules for prevention of accidents with HCPBA.

6. First aid in accidents involving hazardous products.

7. Risk assessment.

8. Introduction to laboratory accreditation.

9. Relevant legislation.

Teaching Methodologies

1. Teaching Methodologies:

Theoretical sessions supported by images. Student participation is encouraged through explanations interpolated with guided discussions and the use of PBL (problem-based learning) methodologies at key points of the classes.

2. Learning Activities:

Combination of classroom activities with activities supported by the Moodle platform available at the University of the Azores: analysis of case studies, labels, MSDS sheets and legislation (material provided by the teacher).

Bibliography

Simões, J.A.M., et al. Guia do Laboratório de Química e Bioquímica, 2ª Edição, Lidel, Lisboa, 2008.

Organização Mundial da Saúde. Manual de segurança biológica em laboratório, 3ª Edição, Genebra, 2004.

Armour, M.-A. Hazardous laboratory chemicals disposal guide, 3rd Ed, Lewis Publishers, 2003.

Uva, A.S. & Faria, M. Exposição profissional a substâncias químicas: diagnóstico das situações de risco, Revista Portuguesa de Saúde Pública 18(1): 5-9, 2000.

Sites:

http://www.unece.org/trans/danger/publi/ghs/ghs_rev02/02files_e.html

“Globally Harmonized System of Classification and Labelling of Chemicals (GHS)”

http://msds.chem.ox.ac.uk/

“The Physical and Theoretical Chemistry Laboratory Oxford University - Chemical and Other Safety Information”

http:physchem.ox.ac.uk/MSDS/incompatibles.html

“Incompatible Chemicals”

http://www.oecd.org/document/1/0,3746,en_2649_37465_48477249_1_1_1_37465,00.html

“OCDE – Good Laboratory Practice (GLP)”

Legislação