Biophysical

Objectives

Objectives
The information provided by this curricular unit is directed to provide the student with the tools that will allow for a more enlightened approach of physical phenomena applied to biological systems as well as develop critical sense necessary to its analysis and interpretation
Understand the theoretical principles of Fluid Mechanics and its application in biological systems
Understand the phenomena of mass transport in its application to biological systems
Understand the characteristics of different types of radiation, specificity and identification of electromagnetic radiation and its clinical applications skills

Understand, describe and apply the knowledge of Biophysics to the pathophysiology of biological systems
Demonstrate adequate capacity for summarizing and communicating
Demonstrate skills that are essential in teamwork and knowledge of the ethical and deontological concepts
underlying the relationship with colleagues, other professionals and patients

Program

1-Biophysics of membranes
Mass transport across biological membranes: Fick laws; permeability; osmotic pressure; Kedem-Katchasky equation
Applications to the urinary system: glomerular filtration, tubular reabsorption and secretion
2-Biophysics fluid
Ideal and real fluids: Energies associated with fluid dynamics: conservation of mass, Bernoulli's theorem,
Poiseuille's law, hydrodynamic power, resistance and Reynolds number
Systemic and pulmonary circulation: differences and hemodynamic changes. Laws that regulate ventilation
and gas exchange
Surface tension: Law of Laplace and applications to elastic membranes: aortic arch, ventricular wall and pulmonary alveoli
Elastic tension: ideal collapsible vessel: West areas of the respiratory system
3-Physics of the atom and the nucleus and medical applications
The atom and the atomic nucleus: importance of ionizing radiation in medicine.
Radiation dosimetry, radiobiology and radiation protection

Teaching Methodologies

In this curricular unit the general structure of the teaching methodologies, will be complementary between lectures (2 hours per week) and theoretical-practical (2 hours per week). In the theoretical lessons the teacher exposes the syllabus content, using the illustration of the physical concepts presented with concrete examples. In the theoretical and practical classes where students (in separate classes of about 20 students)
come together to solve application exercises formulated in order to clarify and correlate the issues addressed in theoretical practice.
Assessment:
Exam:70%
Midterm exam:
Test:30%
Project:
Seminar or study visit report:
Problem solving report:
Research work:
Synthesis work:
Fieldwork or laboratory work:
Other:

Bibliography

Biofísica Médica. JJ Pedroso de Lima. Universidade de Coimbra, 2014
Biofísica Médica - Exercícios práticos. Maria Filomena Botelho e JJ Pedroso de Lima. Universidade de
Coimbra, 2014
Éléments de Biophysique, Tomo I. Grémy F et Leterrier F. Flammarion Médecine-Sciences, 3ª tirage, 1988.
Éléments de Biophysique, Tomo II. Rémy F et Perrin J. Flammarion Médecine-Sciences, 2ª edition, 1977.
Intermediate Physics for Medicine and Biology (Biological and Medical Physics, Biomedical Engineering).
Russell K. Hobbie, Brad Roth. Springer, 2007.
Russell K. Hobbie, Brad Roth. Springer, 2007, "Intermediate Physics for Medicine and Biology (Biological and
Medical Physics, Biomedical Engineering)"