Research Methods II

Objectives

This obligatory semester on quantitative Methods on Fundamental, Pre-clinical, Translational and Clinical Research further consolidates the understanding how biostatistical methods can be used to infer population characteristics based on appropriate samples. The link with modelling and multivariate approaches is consolidated in this Course Unit.

Program

1. Analysis of Variance.
2. Simple and Multiple Linear Regression.
3. Generalized Linear Models: Logistic Regression.
4. Survival Analysis.
5. ROC Curves and Medical Decision.
6. Introduction to Meta-Analysis: Fixed and random effects models.
7. Experimental Design: General concepts and strategies; Sample size determination.

Teaching Methodologies

The theoretical classes will provide a concise review of the material to be covered and its links to previous classes, always with an emphasis on the learning of decision making skills. A theoretical and conceptual analysis is then provided. The next phase will be oriented towards problem based learning using practical examples. Give that in the theoretical classes we discuss problem solving techniques, this provides a direct link to the independent material shown in the pratical classes.

Bibliography

See above.