Physiopathology

Objectives

• Explain the pathophysiological processes of the different agents of disease: mechanical agents, thermoregulation, radiation/electricity, chemicals, living agents, environmental allergens
• Know the main mechanisms of the host response to aggression: inflammation, fever, edema, electrolyte changes, pain, stress, cancer. Demonstrate the capability of identifying the different etiopathogenic parameters. Evaluate laboratory parameters of the inflammatory response.
• Know the pathophysiology of systems/organs and aging: describe the pathophysiology of cardiovascular disease; know the main etiopathogenic mechanisms of anemia and the importance of hemostasis; explain the pathophysiology of respiratory pathology, pathology urinary/renal, maldigestion/malabsorption, hepatic insufficiency, endocrine system. Learn to evaluate disturbances of nutrition. Explain why and how we age and identify the pathophysiological processes of aging.

Program

Disease and its causes:
• Pathophysiology of mechanical agents, thermal regulation, radiation/electricity, chemical and living agents, allergens
Pathophysiology mechanisms of host response to aggression:
• Inflammation
• Febrile syndrome
• Edema
• Electrolytic changes
• Pain
• Stress
• Pathophysiology of oncology
Pathophysiology of systems/organs and maturation:
• Cardiovascular: ischemia, infarction, thrombosis, embolism and gangrene. Shock, heart failure, hypertension
• Hematopoietic system: anemia and modulation hemostasis
• Respiratory: respiratory insufficiency

• Renal/urinary system: renal failure, renal colic, obstruction of the excretory/the acute scrotum, urinary tract infections, prostate
• Digestive: maldigestion/malabsorption, ileus and hepatic insufficiency
• Endocrine system: pathophysiology of pituitary, thyroid, parathyroid, adrenal and pancreas
• Nutrition: obesity, malnutrition, dyslipidemia, gout, vitamin deficiencies
• Ageing

Teaching Methodologies

Theoretical classes:
• Prior assessment of students' level of knowledge.
• Formulation of objectives.
• Use of handouts.
• Structuring of classes based on the analysis of a problem

• Clarification of questions that promote reasoning.
• Group discussion (buzz groups).
• Discussion that allows a post-lecture assessment.
• Lecturing complemented by a brief final summary.
Practical Classes
• Problem-based learning.
• Case Studies.
• Analysis of documents.
• Presentations carried out by students.
• Experiential learning
• Conceptual maps
Seminars Pathophysiology/Pharmacology

Assessment:
Exam:70%
Midterm exam:
Test:20%
Other:10% - Continuous assessment (Presença e avaliação dos seminários[1v]; Análise de artigos científicos
[0.60v]; Assiduidade às aulas práticas [0.40])

Bibliography

Mota-Pinto, A. Fisiopatologia – Fundamentos e Aplicações. 1. ed. Lisboa: Lidel, Edições Técnicas, 2007. v. 1. 546 p. Copyright © Outubro de 2007/Reimpressão – Janeiro de 2009/ 2ª edição revista em 2013